Description
Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly.The kindling model was first proposed in the late 1960s by Goddard and colleagues. Although kindling is a widely used model, its applicability to human epilepsy is controversial.
Already in the 1950s and 1960s, numerous authors recognized the seizure-inducing potential of focal stimulation.Here, Delgado and Sevillano demonstrated that repeated low-intensity stimuli to the hippocampus could lead to progressive increase of electrically evoked seizure activity.Yet, it was not until the late 1960s that Graham Goddard recognized the potential importance of this phenomenon and coined the term 'kindling. Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory.
The publication of these results opened an completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy.
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